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Symbol
Name
ID

Spta1
spectrin alpha, erythrocytic 1
MGI:98385

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Splenomegaly	Maculopapular exanthema
Disease(s) Associated with SPTA1	Splenomegaly	Maculopapular exanthema
hereditary spherocytosis

Mouse Phenotypes

increased B cell proliferation

increased T cell proliferation

enlarged spleen

increased spleen weight

increased neutrophil cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased T cell number

increased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal spleen morphology

decreased spleen iron level

abnormal splenic cell ratio

increased IgA level

increased IgG level

abnormal lymph node cell ratio

lymph node hyperplasia

glomerulonephritis

tubular nephritis

alveolitis

interstitial pneumonia

increased susceptibility to bacterial infection

decreased susceptibility to parasitic infection

Availability

Mouse Genotype

Spta1^ihj/Spta1^ihj

Spta1^sph-2Bc/Spta1^sph-2Bc

Spta1^sph-3J/Spta1^sph-3J

Spta1^sph-4J/Spta1^sph-4J

Spta1^sph-Dem/Spta1^sph-Dem

Spta1^sph-ha/Spta1^sph-ha

Spta1^sph/Spta1^sph

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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